The Royal Society
Browse

Supplementary material from "One-pot domino syntheses of 3-alkyl-3-N-substituted aminobenzofuran- 2(3H)-ones based on alkali-promoted Michael addition and lactonization"

Posted on 2024-02-08 - 14:09
In this paper, a novel cascade reaction of caesium carbonate-promoted Michael addition and lactonization for the one-pot synthesis of 3-alkyl-3-N-substituted aminobenzofuran-2(3H)-one derivatives has been established based on the screening of the alkaline catalysts and optimization of reaction conditions, in which the N-substituted (ortho-hydroxy) aryl glycine esters were used as the Michael donors to react with different α, β-unsaturated carbonyl compounds. Besides racemic enantiomers, the obtained epimers were successfully separated by conventional chromatography in the case of using the asymmetric raw material. In addition, the possible reaction mechanisms were suggested and the absolute configuration of the epimer was analysed. All the chemical structures of unreported benzofuran- 2(3H)-one derivatives were characterized by IR, 1H NMR, 13C NMR spectra and HRMS spectra.

CITE THIS COLLECTION

DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
or
Select your citation style and then place your mouse over the citation text to select it.

SHARE

email
need help?