Supplementary material from "One-pot domino syntheses of 3-alkyl-3-N-substituted aminobenzofuran- 2(3H)-ones based on alkali-promoted Michael addition and lactonization"
Posted on 2024-02-08 - 14:09
In this paper, a novel cascade reaction of caesium carbonate-promoted Michael addition and lactonization for the one-pot synthesis of 3-alkyl-3-N-substituted aminobenzofuran-2(3H)-one derivatives has been established based on the screening of the alkaline catalysts and optimization of reaction conditions, in which the N-substituted (ortho-hydroxy) aryl glycine esters were used as the Michael donors to react with different α, β-unsaturated carbonyl compounds. Besides racemic enantiomers, the obtained epimers were successfully separated by conventional chromatography in the case of using the asymmetric raw material. In addition, the possible reaction mechanisms were suggested and the absolute configuration of the epimer was analysed. All the chemical structures of unreported benzofuran- 2(3H)-one derivatives were characterized by IR, 1H NMR, 13C NMR spectra and HRMS spectra.
CITE THIS COLLECTION
3D Printing in Medicine
3D-Printed Materials and Systems
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
chu, Xiao-Hui; Gao, Na; Wang, Wei; Zheng, Zhong; Wang, Jin-Jun (2024). Supplementary material from "One-pot domino syntheses of 3-alkyl-3-N-substituted aminobenzofuran- 2(3H)-ones based on alkali-promoted Michael addition and lactonization". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.7065720.v1
Select your citation style and then place your mouse over the citation text to select it.