Supplementary material from "Loss of TOP3B leads to increased R-loop formation and genome instability"
Posted on 2019-11-15 - 11:59
Topoisomerase III beta (TOP3B) is one of the least-understood members of the topoisomerase family of proteins and remains enigmatic. Our recent data shed light on the function and relevance of TOP3B to disease. A homozygous deletion for the TOP3B gene was identified in a patient with bilateral renal cancer. Analyses in both patient and modelled human cells show the disruption of TOP3B causes genome instability with a rise in DNA damage and chromosome bridging (mis-segregation). The primary molecular defect underlying this pathology is a significant increase in R-loop formation. Our data show that TOP3B is necessary to prevent the accumulation of excessive R-loops and identify TOP3B as a putative cancer gene and support recent data show that R-loops are involved in cancer aetiology.
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Zhang, Tao; Wallis, Mathew; Petrovic, Vida; Challis, Jackie; Kalitsis, Paul; Hudson, Damien F. (2019). Supplementary material from "Loss of TOP3B leads to increased R-loop formation and genome instability". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.4740857.v1