Supplementary material from "Independent natural genetic variation of punishment- versus relief-memory"
Posted on 2016-12-07 - 13:39
A painful event establishes two opponent memories: Cues that are associated with pain onset are remembered negatively; whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment- versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment- and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications.
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Appel, Mirjam; Scholz, Claus-Jürgen; Kocabey, Samet; Savage, Sinead; König, Christian; Yarali, Ayse (2016). Supplementary material from "Independent natural genetic variation of punishment- versus relief-memory". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.3590393.v1
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AUTHORS (6)
MA
Mirjam Appel
CS
Claus-Jürgen Scholz
SK
Samet Kocabey
SS
Sinead Savage
CK
Christian König
AY
Ayse Yarali