Supplementary material from "Enantioselective synthesis of a costic acid analogue with acaricidal activity against the bee parasite <i>Varroa destructor</i>"

Published on 2020-09-15T05:32:04Z (GMT) by
One major disease of the pupae and the adult bees is the so-called <i>Varroosis</i> that is due to the bee parasite <i>Varroa destructor</i>. It is an ectoparasite of bees, causing significant losses in bee population needed for honey production as well as for pollination in agriculture. Costic acid is a sesquiterpene-carboxylic acid present in the plant <i>Dittrichia viscosa</i>. Recent studies by our group have shown that costic acid acts as acaricide against <i>V. destructor</i>. Oxalic acid is also an acaricide commonly used against varroa mites. In spite of its structural simplicity—it is the simplest bicarboxlic acid—it is equipotent to costic acid which consists of a <i>trans</i>-decalin system with three chiral centres. The basic goal of this project was to design and synthesize a hybrid entity, incorporating aspects of both oxalic acid and costic acid that would be more active than the parent compounds. This approach introduces a useful strategy for the preparation of congeners of bioactive compounds and proposes a structural framework for a new series of acaricidal agents.

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Georgiladaki, S.; Isaakidis, D.; Spyros, A.; Tsikalas, G. K.; Katerinopoulos, H. E. (2020): Supplementary material from "Enantioselective synthesis of a costic acid analogue with acaricidal activity against the bee parasite Varroa destructor". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.5104317.v2