Supplementary material from "Elucidation of the hierarchical structure of natural eumelanins"
Posted on 2018-02-20 - 16:57
Eumelanin is one of the most ubiquitous pigments in living organisms and plays an important role in colouration and UV protection. Because eumelanin is highly cross-linked and insoluble in solvents, the chemical structure is still not completely known. In this study, we used atomic force microscopy, X-ray photoelectron spectroscopy and solid-state NMR to compare intact eumelanosomes (pigment granules mostly made of eumelanin) from four phylogentically distant species: cuttlefish (Sepia officinalis) inks, black coloured fish crow (Corvus ossifragus) feathers, iridescent wild turkey (Melleagris gallopavo) feathers and black coloured human hair. We found that eumelanosomes from all four species are composed of subunit nanoparticles with a length of 10–60 nm, consistent with earlier observations in eumelanosomes from the sepia ink and human hair. The solid-state NMR results indicate the presence of quinone methide tautomers in all four eumelanins. We also found clear differences in the UV absorbance, the ratio of 5,6-dihydroxyindole-2-carboxylic acid/5,6-dihydroxyindole and protonated aryl carbon ratios in sepia eumelanin relative to the other three. This comparison of natural eumelanin across a phylogenetically broad group of organisms provides insights into the change in the eumelanin structure over the evolutionary history and enables the production of synthetic eumelanin with properties that are similar to natural eumelanin.
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Xiao, Ming; Chen, Wei; Li, Weiyao; Zhao, Jiuzhou; Hong, You-lee; Nishiyama, Yusuke; et al. (2018). Supplementary material from "Elucidation of the hierarchical structure of natural eumelanins". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.4010347.v1
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AUTHORS (9)
MX
Ming Xiao
WC
Wei Chen
WL
Weiyao Li
JZ
Jiuzhou Zhao
YH
You-lee Hong
YN
Yusuke Nishiyama
TM
Toshikazu Miyoshi
MS
Matthew D. Shawkey
AD
Ali Dhinojwala