Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants"
Version 2 2023-05-29, 18:38
Version 1 2023-05-12, 07:11
Posted on 2023-05-12 - 07:11
The muskox and reindeer are the only ruminants that have evolved to survive in harsh Arctic environments. However, the genetic basis of this Arctic adaptation remains largely unclear. Here, we compared a de novo assembled muskox genome with reindeer and other ruminant genomes to identify convergent amino acid substitutions, rapidly evolving genes and positively selected genes among the two Arctic ruminants. We found these candidate genes were mainly involved in brown adipose tissue (BAT) thermogenesis and circadian rhythm. Furthermore, by integrating transcriptomic data from goat adipose tissues (white and brown), we demonstrated that muskox and reindeer may have evolved modulating mitochondrion, lipid metabolism and angiogenesis pathways to enhance BAT thermogenesis. In addition, results from co-immunoprecipitation (Co-IP) experiments prove that convergent amino acid substitution of the angiogenesis-related gene hypoxia-inducible factor 2 alpha (HIF2A), resulting in weakening of its interaction with prolyl hydroxylase domain-containing protein 2 (PHD2), may increase angiogenesis of BAT. Altogether, our work provides new insights into the molecular mechanisms involved in Arctic adaptation.
CITE THIS COLLECTION
DataCite
3 Biotech
3D Printing in Medicine
3D Research
3D-Printed Materials and Systems
4OR
AAPG Bulletin
AAPS Open
AAPS PharmSciTech
Abhandlungen aus dem Mathematischen Seminar der Universität Hamburg
ABI Technik (German)
Academic Medicine
Academic Pediatrics
Academic Psychiatry
Academic Questions
Academy of Management Discoveries
Academy of Management Journal
Academy of Management Learning and Education
Academy of Management Perspectives
Academy of Management Proceedings
Academy of Management Review
Li, Manman; Li, Xinmei; Wu, Zhipei; Zhang, Guanghui; Wang, Nini; Dou, Mingle; et al. (2023). Supplementary material from "Convergent molecular evolution of thermogenesis and circadian rhythm in Arctic ruminants". The Royal Society. Collection. https://doi.org/10.6084/m9.figshare.c.6644026.v1
or
Select your citation style and then place your mouse over the citation text to select it.
SHARE
Usage metrics
Read the peer-reviewed publication
AUTHORS (18)
ML
Manman Li
XL
Xinmei Li
ZW
Zhipei Wu
GZ
Guanghui Zhang
NW
Nini Wang
MD
Mingle Dou
SL
Shanlin Liu
CY
Chentao Yang
GM
Guanliang Meng
HS
Hailu Sun
CH
Christina Hvilsom
GX
Guoxiang Xie
YL
Yang Li
ZL
Zhuo hui Li
WW
Wei Wang
YJ
Yu Jiang
RH
Rasmus Heller
YW
Yu Wang