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Supplemental Figure 1. Loss of Gradient slows down Notch selection from Active perception during angiogenesis: filopodia speed up Notch selection of tip cells in silico and in vivo

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posted on 29.12.2020, 08:22 by Bahti Zakirov, Georgios Charalambous, Raphael Thuret, Irene M. Aspalter, Kelvin Van-Vuuren, Thomas Mead, Kyle Harrington, Erzsébet Ravasz Regan, Shane Paul Herbert, Katie Bentley
a)Violin plots showing that in completely uniform Vegf (no gradient) slows down selection (“time to pattern”) of the in silico for control (0.8) and LOF Vegf (0.4) concentrations compared to simulations with a vegf gradient (Fig 2b,c). Altering filopodial activity fails to rescue this. Blue shading corresponds to estimated probability density of timing values in that range. Upward arrows indicate pattern not achieved within the time range of the simulation for the corresponding parameter settings. Horizontal pink line indicates median value, horizontal black lines indicate middle quartiles, whiskers indicate upper and lower quartiles. N=100 simulations ran for 5000 timesteps.