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Derivations and numerical examples of the equations discussed in Sections 2 and 3 from The affinity-efficacy problem: an essential part of pharmacology education

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Version 2 2024-07-04, 10:40
Version 1 2024-06-26, 11:43
journal contribution
posted on 2024-07-04, 10:40 authored by James Higham, David Colquhoun
This file contains three parts: (1) contains a derivation of the equations for the occupancy of each state in the del Castillo-Katz mechanism; (2) contains two numerical examples of the matrix approach, one for the del Castillo-Katz mechanism and one for the 1985 nAChR mechanism which is used as an example in section 3 of the main text (we also show the derivation of equations for the occupancy of each state in this mechanism, as was done for the del Castillo-Katz mechanism); (3) contains a discussion of constitutive receptor activity and inverse agonism, demonstrating the relationship between these phenomena and the affinity-efficacy problem.

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