Supplementary Figures S1 to S15 with legends from Sex-specific adaptation and genomic responses to Y chromosome presence in female reproductive and neural tissues
journal contributionposted on 22.11.2017 by Alan T. Branco, Rute Brito, Bernardo Lemos
Any type of content formally published in an academic journal, usually following a peer-review process.
Y chromosomes typically harbour a small number of genes and an abundance of repetitive sequences. In Drosophila, the Y chromosome comprises multimegabase long segments of repetitive DNA and a handful of protein-coding genes. In mammals, the Y chromosome also harbours a disproportionally high abundance of repeats. Here, we build on a Drosophila melanogaster model in which the Y chromosome is decoupled from sexual determination. The genotypes were genetically identical for the autosomes, X chromosome, and mitochondria, but differ by the presence or dose of the Y chromosome. Addition of an extra Y chromosome had limited impact in males. However, the presence of a Y chromosome in females induced a disproportionate response in genes expressed in the ovaries as well as genes encoded by the mitochondrial genome. Furthermore, the data revealed significant consequences of Y chromosome presence in larvae neuronal tissue. This included the repression of genes implicated in reproductive behaviour, courtship, mating and synaptic function. Our findings exhibit the Y chromosome as a hotspot for sex-specific adaptation. They suggest a role of natural selection on Y-linked genetic elements exerting impacts on sex-specific tissues as well as somatic tissues shared by males and females.