Figure S2 from Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells

Comparison of sensitivity for all gold standard L1Hs and only heterozygous non-reference insertions. Black, bulk DNA TIPseq; red, MDA whole genome amplification followed by restriction enzyme digestion and ligation with vectorette adaptors (MDA-D); orange, MDA whole genome amplification followed by end repair, dA tailing and ligation with dT vectorette adaptor (MDA-T); dark blue, MALBAC whole genome amplification followed by ligation with dT vectorette adaptor (MALBAC-T). Diamond, bulk DNA TIPseq; circle, whole genome amplification using random hexamers only (R); square, whole genome amplification using random hexamers and L1 primer (RL).