Fig_4.tif (3.54 MB)

Quantification of E, NE, MN and NMN in plasma and tumor tissue of PGL, mixed and NorAd tumors.

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posted on 2015-05-06, 04:01 authored by Eric Grouzmann, Oliver Tschopp, Frédéric Triponez, Maurice Matter, Stefan Bilz, Michael Brändle, Tilman Drechser, Sarah Sigrist, Henryk Zulewski, Christoph Henzen, Stefan Fischli, Karim Abid

(A) Quantification of epinephrine (E), norepinephrine (NE), total CAT (E+NE) and NE/E ratio from 30 mixed PHEO (Mix, open diamonds); 23 noradrenergic PHEO (NorAd, filled diamonds) and 13 PGL (open circles) samples. Results are given in nanomoles per gram of tissue and represented on a logarithmic scale. Geographic mean and standard deviation for each group are reported in supporting information (S4 Table). (B) Same as in A, quantification of CAT in plasma for 28 mixed PHEO, 22 NorAd PHEO and 23 PGL. (C) Quantification of MN and NMN sum of MNs (MN+NMN) and NMN/MN ratio from 30 mixed PHEO (Mix, open diamonds); 23 NorAd PHEO (filled diamonds) and 13 PGL (open circles) samples. (D) Same as in C, quantification of MNs in plasma for 28 mixed PHEO, 22 NorAd PHEO and 23 PGL. ***P<0.001, **P<0.01, *P<0.05, ns: not statistically significant. For CAT and MNs in tumor tissue, minimal values were set at 0.1 nmol/g representing limit of quantification.