Fig_2.tif (1.83 MB)

Quantification of E, NE, MN and NMN in plasma and tumor tissue.

figure

posted on 2015-05-06, 04:01 authored by Eric Grouzmann, Oliver Tschopp, Frédéric Triponez, Maurice Matter, Stefan Bilz, Michael Brändle, Tilman Drechser, Sarah Sigrist, Henryk Zulewski, Christoph Henzen, Stefan Fischli, Karim Abid

(A) Quantification of epinephrine (E), norepinephrine (NE), total CATs (E+NE) and NE/E ratio from 53 PHEO (filled circles) and 13 PGL (open circles) samples. Results are given in nanomoles per gram of tissue and represented on a logarithmic scale. Geographic mean and standard deviation for each group are reported in supporting information (S2 Table). (B) Same as in A, quantification of CAT in plasma for 50 PHEO and 23 PGL. (C) Quantification of metanephrine (MN), normetanephrine (NMN), sum of metanephrines (MN+NMN) and NMN/MN ratio from 53 PHEO (filled circles) and 13 PGL (open circles).(D) Same as in C, quantification of metanephrines in plasma for 51 PHEO and 23 PGL. ***P<0.001, **P<0.01, *P<0.05, ns: not statistically significant. For CAT and metanephrines in tumor tissue, minimal values were set at 0.1 nmol/g representing limit of quantification.