Supporting Information from Robust synchronization of cell cycle and circadian clock through bidirectional coupling

2019-09-03T11:51:08Z (GMT) by Jie Yan Albert Goldbeter
1. Model for bidirectional coupling of cell cycle and circadian clock …..………………… p.1 / 2. Coupling the cell cycle to the circadian clock via induction of Wee1 by BMAL1. / 3. Coupling the circadian clock to the cell cycle via phosphorylation of REV-ERBα by Cyclin B/CDK1. / 4. Coupling the cell cycle to the circadian clock via indirect repression of Cyclin E by BMAL1. / 5. Coupling the circadian clock to the cell cycle via inhibition by Cyclin B/CDK1 of transcription at mitosis. /6. Coupling the circadian clock to light-dark (LD) cycle by inducing the transcription of Per mRNA. /7. Coupling the circadian clock to the cell cycle via putative phosphorylation of BMAL1 by Cyclin B/CDK1./ 8. Variables and parameters in Eqs. (1) – (11). / 9. Initial conditions for numerical simulations. /10. Figures S1-S9. / 11. Computer code for numerical simulations of the model for bidirectional coupling of cell cycle and circadian clock. / 12. References for Supporting Informations