Strain distribution over an axon embedded in a collagen fiber network undergoing axial and shear loading from Tissue loading and microstructure regulate the deformation of embedded nerve fibres: predictions from single-scale and multiscale simulations

Maximum principal Green strain field on a representative axon in an initially isotropic fiber network (fiber volume concentration=0.3) deformed during axial (left) and shear (right) loading. Although the axon's shape follows the gross boundary displacement, the strain field is highly localized. The gray meshed configurations represent the undeformed state.( Vahhab Zarei, Sijia Zhang, Beth A. Winkelstein, Victor H. Barocas. “Tissue loading and microstructure regulate the deformation of embedded nerve fibers: predictions from single-scale and multiscale simulations”. Journal of Royal Society Interface.)