Synthetic and biological experiments from N<i><sup>ε</sup></i>-acetyl-lysine derivatives with zinc binding groups as novel HDAC inhibitors
Fang Wang
Chun Wang
Jie Wang
Yefang Zou
Xiaoxue Chen
Ting Liu
Yan Li
Yonglong Zhao
Yongjun Li
Bin He
10.6084/m9.figshare.8152961.v1
https://rs.figshare.com/articles/journal_contribution/Synthetic_and_biological_experiments_from_N_i_sup_sup_i_-acetyl-lysine_derivatives_with_zinc_binding_groups_as_novel_HDAC_inhibitors/8152961
HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from N<sup>ε</sup>-acetyl lysine. In current study, we raised a novel design, which is about N<sup>ε</sup>-acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.
2019-05-20 11:10:03
Nε-acetyl lysine
ZBG group
analogues
hybridization
HDAC inhibitor