10.6084/m9.figshare.7007411.v1
Federico Battiston
Federico
Battiston
Jeremy Guillon
Jeremy
Guillon
Mario Chavez
Mario
Chavez
Vito Latora
Vito
Latora
Fabrizio De Vico Fallani
Fabrizio
De Vico Fallani
Figure S3 from Multiplex core–periphery organization of the human connectome
The Royal Society
2018
complex networks
multilayer networks
rich-club
brain connectivity
multimodal integration
2018-08-24 08:46:03
Journal contribution
https://rs.figshare.com/articles/journal_contribution/Figure_S3_from_Multiplex_core_periphery_organization_of_the_human_connectome/7007411
What is the core of the human brain is a fundamental question that has been mainly addressed by studying the anatomical connections between differently specialized areas, thus neglecting the possible contributions from their functional interactions. While many methods are available to identify the core of a network when connections between nodes are all of the same type, a principled approach to define the core when multiple types of connectivity are allowed is still lacking. Here, we introduce a general framework to define and extract the core–periphery structure of multi-layer networks by explicitly taking into account the connectivity patterns at each layer. We first validate our algorithm on synthetic networks of different size and density, and with tunable overlap between the cores at different layers. We then use our method to merge information from structural and functional brain networks, obtaining in this way an integrated description of the core of the human connectome. Results confirm the role of the main known cortical and subcortical hubs, but also suggest the presence of new areas in the sensori-motor cortex that are crucial for the intrinsic brain functioning. Taken together these findings provide fresh evidence on a fundamental question in modern neuroscience and offer new opportunities to explore the mesoscale properties of multimodal brain networks.